The role of defensive ecological interactions in the evolution of conotoxins.
Identifieur interne : 001553 ( Main/Exploration ); précédent : 001552; suivant : 001554The role of defensive ecological interactions in the evolution of conotoxins.
Auteurs : J R Prashanth [Australie] ; S. Dutertre [Australie] ; A H Jin [Australie] ; V. Lavergne [Australie] ; B. Hamilton [Australie] ; F C Cardoso [Australie] ; J. Griffin [Australie] ; D J Venter [Australie] ; P F Alewood [Australie] ; R J Lewis [Australie]Source :
- Molecular ecology [ 1365-294X ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Conotoxins.
- chemical , genetics : Conotoxins.
- geographic : Australia.
- genetics : Conus Snail.
- Amino Acid Sequence, Animals, Cell Line, Evolution, Molecular, Humans, Molecular Sequence Data, Phylogeny, Sequence Analysis, RNA, Tandem Mass Spectrometry, Transcriptome.
Abstract
Venoms comprise of complex mixtures of peptides evolved for predation and defensive purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in response to predatory or defensive stimuli, providing a unique opportunity to study separately how different ecological pressures contribute to toxin diversification. Here, we report the extraordinary defensive strategy of the Rhizoconus subgenus of cone snails. The defensive venom from this worm-hunting subgenus is unusually simple, almost exclusively composed of αD-conotoxins instead of the ubiquitous αA-conotoxins found in the more complex defensive venom of mollusc- and fish-hunting cone snails. A similarly compartmentalized venom gland as those observed in the other dietary groups facilitates the deployment of this defensive venom. Transcriptomic analysis of a Conus vexillum venom gland revealed the αD-conotoxins as the major transcripts, with lower amounts of 15 known and four new conotoxin superfamilies also detected with likely roles in prey capture. Our phylogenetic and molecular evolution analysis of the αD-conotoxins from five subgenera of cone snails suggests they evolved episodically as part of a defensive strategy in the Rhizoconus subgenus. Thus, our results demonstrate an important role for defence in the evolution of conotoxins.
DOI: 10.1111/mec.13504
PubMed: 26614983
Affiliations:
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Dutertre</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Jin, A H" sort="Jin, A H" uniqKey="Jin A" first="A H" last="Jin">A H Jin</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Lavergne, V" sort="Lavergne, V" uniqKey="Lavergne V" first="V" last="Lavergne">V. Lavergne</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Hamilton, B" sort="Hamilton, B" uniqKey="Hamilton B" first="B" last="Hamilton">B. Hamilton</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101</wicri:regionArea><wicri:noRegion>4101</wicri:noRegion></affiliation></author><author><name sortKey="Cardoso, F C" sort="Cardoso, F C" uniqKey="Cardoso F" first="F C" last="Cardoso">F C Cardoso</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Griffin, J" sort="Griffin, J" uniqKey="Griffin J" first="J" last="Griffin">J. Griffin</name><affiliation wicri:level="1"><nlm:affiliation>ACRF Microscopy Facility, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ACRF Microscopy Facility, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Venter, D J" sort="Venter, D J" uniqKey="Venter D" first="D J" last="Venter">D J Venter</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Pathology, Mater Health Services, Raymond Terrace, South Brisbane, Qld, 4101</wicri:regionArea><wicri:noRegion>4101</wicri:noRegion></affiliation></author><author><name sortKey="Alewood, P F" sort="Alewood, P F" uniqKey="Alewood P" first="P F" last="Alewood">P F Alewood</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, R J" sort="Lewis, R J" uniqKey="Lewis R" first="R J" last="Lewis">R J Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, 4072</wicri:regionArea><wicri:noRegion>4072</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular ecology</title><idno type="eISSN">1365-294X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Australia</term><term>Cell Line</term><term>Conotoxins (chemistry)</term><term>Conotoxins (genetics)</term><term>Conus Snail (genetics)</term><term>Evolution, Molecular</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Analysis, RNA</term><term>Tandem Mass Spectrometry</term><term>Transcriptome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Australie</term><term>Conotoxines ()</term><term>Conotoxines (génétique)</term><term>Conus (génétique)</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Spectrométrie de masse en tandem</term><term>Séquence d'acides aminés</term><term>Transcriptome</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Conotoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Conotoxins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Australia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conus Snail</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Conotoxines</term><term>Conus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cell Line</term><term>Evolution, Molecular</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Analysis, RNA</term><term>Tandem Mass Spectrometry</term><term>Transcriptome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Australie</term><term>Conotoxines</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Spectrométrie de masse en tandem</term><term>Séquence d'acides aminés</term><term>Transcriptome</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Venoms comprise of complex mixtures of peptides evolved for predation and defensive purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in response to predatory or defensive stimuli, providing a unique opportunity to study separately how different ecological pressures contribute to toxin diversification. Here, we report the extraordinary defensive strategy of the Rhizoconus subgenus of cone snails. The defensive venom from this worm-hunting subgenus is unusually simple, almost exclusively composed of αD-conotoxins instead of the ubiquitous αA-conotoxins found in the more complex defensive venom of mollusc- and fish-hunting cone snails. A similarly compartmentalized venom gland as those observed in the other dietary groups facilitates the deployment of this defensive venom. Transcriptomic analysis of a Conus vexillum venom gland revealed the αD-conotoxins as the major transcripts, with lower amounts of 15 known and four new conotoxin superfamilies also detected with likely roles in prey capture. Our phylogenetic and molecular evolution analysis of the αD-conotoxins from five subgenera of cone snails suggests they evolved episodically as part of a defensive strategy in the Rhizoconus subgenus. Thus, our results demonstrate an important role for defence in the evolution of conotoxins.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Prashanth, J R" sort="Prashanth, J R" uniqKey="Prashanth J" first="J R" last="Prashanth">J R Prashanth</name></noRegion><name sortKey="Alewood, P F" sort="Alewood, P F" uniqKey="Alewood P" first="P F" last="Alewood">P F Alewood</name><name sortKey="Cardoso, F C" sort="Cardoso, F C" uniqKey="Cardoso F" first="F C" last="Cardoso">F C Cardoso</name><name sortKey="Dutertre, S" sort="Dutertre, S" uniqKey="Dutertre S" first="S" last="Dutertre">S. Dutertre</name><name sortKey="Griffin, J" sort="Griffin, J" uniqKey="Griffin J" first="J" last="Griffin">J. Griffin</name><name sortKey="Hamilton, B" sort="Hamilton, B" uniqKey="Hamilton B" first="B" last="Hamilton">B. Hamilton</name><name sortKey="Jin, A H" sort="Jin, A H" uniqKey="Jin A" first="A H" last="Jin">A H Jin</name><name sortKey="Lavergne, V" sort="Lavergne, V" uniqKey="Lavergne V" first="V" last="Lavergne">V. Lavergne</name><name sortKey="Lewis, R J" sort="Lewis, R J" uniqKey="Lewis R" first="R J" last="Lewis">R J Lewis</name><name sortKey="Venter, D J" sort="Venter, D J" uniqKey="Venter D" first="D J" last="Venter">D J Venter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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